Weight Management - Follow Up on our Discussion...

Follow up on our discussion on the benefits of consuming C8 KetoMCT oil for Weight Management

Background: As noted in our primer, two large “meta analyses” (combining data from numerous individual studies) previously showed that intake of MCTs result in a reduction of body weight and body fat, with no reduction in lean fat mass26, 36. Increased thermogenesis (due to rapid and excessive oxidation of MCFA) and improved satiety (less calories consumed at subsequent meals) are two mechanisms involved.

Results: In a recent study with 19 healthy subjects, both conjugated linoleic acid (CLA) and MCT intake resulted in less energy intake than control throughout the day, indicating satiety benefits6. MCTs affect appetite and satiety. Ghrelin is a stomach peptide that increases appetite and suppresses energy expenditure. One mechanism of MCTs could involve octanoylation (addition of octanoic acid from C8 MCTs) of the hormone ghrelin22. Since this would increase appetite (by activating ghrelin), more physiological studies in vivo (in living organisms) are needed. In a study with Japanese anorexia nervosa patients (an eating disorder resulting in emaciation), more than 6 grams MCT (Nestle clinical nasal formulations) per day increased ghrelin octanoylation, and increased neuropeptide Y (NPY) levels (NPY increases appetite), but without increasing body weight20. A caveat in the study was that the energy intake of the diets was fixed.

Conclusions: Although the mechanism is not fully understood, MCTs, and particularly C8, have been established to result in loss in fat mass, without loss in lean body mass. It is likely that MCTs could be combined with other nutrients to achieve additive or synergistic benefits. Possible weight gain with MCT is being evaluated in clinical conditions such as anorexia nervosa, cancer cachexia via TPN37, during radiotherapy21, and chronic respiratory deficiency.

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6.    Coleman, H., P. Quinn, and M.E. Clegg, Medium-chain triglycerides and conjugated linoleic acids in beverage form increase satiety and reduce food intake in humans. Nutr Res, 2016. 36(6): p. 526-533.
20.  Kawai, K., et al., Ghrelin activation and neuropeptide Y elevation in response to medium chain triglyceride administration in anorexia nervosa patients. Clinical Nutrition ESPEN, 2017. 17: p. 100–104.
21.  Klement, R.J. and R.A. Sweeney, Impact of a ketogenic diet intervention during radiotherapy on body composition: II. Protocol of a randomised phase I study (KETOCOMP). Clinical Nutrition ESPEN, 2016. 12: p. e1-e6.
22.  Lemarie, F., et al., Revisiting the metabolism and physiological functions of caprylic acid (C8:0) with special focus on ghrelin octanoylation. Biochimie, 2016. 120: p. 40-48.
26.  Mumme, K. and W. Stonehouse, Effects of medium-chain triglycerides on weight loss and body composition: a meta-analysis of randomized controlled trials. J Acad Nutr Diet, 2015. 115(2): p. 249-263.
36.  St-Onge, M.P. and P.J. Jones, Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. J Nutr, 2002. 132(3): p. 329-332.
37.  Szefel, J., et al., Medium-chain triglycerides/long-chain triglycerides versus long-chain triglycerides in treatment of cancer patients with major body mass loss. Survival in patients with refractory cachexia. Prz Gastroenterol, 2016. 11(3): p. 181-186.

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